Lithium Hydroxide → 3-(2,2,2-Trifluoroethoxy)pyridine-2-carboxylic acid
反応式
C[O:2][C:3]([C:5]1[C:10]([O:11][CH2:12][C:13]([F:16])([F:15])[F:14])=[CH:9][CH:8]=[CH:7][N:6]=1)=[O:4].[OH-].[Li+]>CO.O>[F:16][C:13]([F:14])([F:15])[CH2:12][O:11][C:10]1[C:5]([C:3]([OH:4])=[O:2])=[N:6][CH:7]=[CH:8][CH:9]=1参加物
5
実験手順
A solution of 3-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid methyl ester (216 mg, 0.9 mmol) in methanol (1 ml) was treated with a solution of lithium hydroxide (78 mg, 3.3 mmol) in water (0.1 ml) and stirring was continued at 22° C. for 2 hours. The solution was evaporated and the residue triturated with 1N aqueous hydrochloric acid. The suspension was filtered, the residue washed with water and dried to give 3-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid as a colorless solid. MS (ISN): m/z=220 [M−H]−.
後処理
- customThe solution was evaporated
- customthe residue triturated with 1N aqueous hydrochloric acid
- filtrationThe suspension was filtered
- washthe residue washed with water
- customdried
出典と根拠
- ORDレコード
- ord-db7e7c34baea41cbb7c0f56e6ca1b703
- 出典データセット
- uspto-grants-2015_08
- 特許番号
- US09115098B2
反応ノート
読み込み中…