Trifluoroacetic acid → (2E)-3-[5-(benzyloxycarbonyl)furan-2-yl]-2-propenoic acid

反応式

[CH2:1]([O:8][C:9]([C:11]1[O:12][C:13]([CH:16]=[CH:17][C:18]([O:20]C(C)(C)C)=[O:19])=[CH:14][CH:15]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.FC(F)(F)C(O)=O>>[CH2:1]([O:8][C:9]([C:11]1[O:12][C:13](/[CH:16]=[CH:17]/[C:18]([OH:20])=[O:19])=[CH:14][CH:15]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

反応物 2

HCID 6422Trifluoroacetic acid

HCID 779345505-(2-tert-Butoxycarbonylethenyl)furan-2-carboxylic acid benzyl ester

生成物 1

HCID 70869499(2E)-3-[5-(benzyloxycarbonyl)furan-2-yl]-2-propenoic acid

実験手順

To 5-(2-tert-butoxycarbonylethenyl)furan-2-carboxylic acid benzyl ester (0.15 g, 0.46 mmol) obtained in Example 41, step 2 was added trifluoroacetic acid (3 mL), and the mixture was stirred for 30 minutes. The solvent was evaporated under reduced pressure to give the title compound.

後処理

customThe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード: ord-f491899c07b74235a3fb6af232a38953
出典データセット: uspto-grants-2015_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09115107B2

反応ノート

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