Methanol → L-cysteic acid methyl ester hydrochloride

HRID 517340

反応式

HRID 517340 の反応式
[NH2:1][C@H:2]([C:8]([OH:10])=[O:9])[CH2:3][S:4](=[O:7])([OH:6])=[O:5].S(Cl)([Cl:13])=O.[CH3:15]O>>[ClH:13].[CH3:15][O:9][C:8](=[O:10])[C@H:2]([CH2:3][S:4](=[O:6])([OH:7])=[O:5])[NH2:1]

参加物

4

反応物 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 72886L-Cysteic acid

生成物 1

HCID 86673321L-cysteic acid methyl ester hydrochloride収率 75%

実験手順

L-cysteic acid (300 mg, 1.77 mmol) was dissolved in methanol (12 mL), and thionyl chloride (2.5 mL, 34 mmol) was slowly added at 0° C. After stirring at room temperature overnight, the reaction mixture was concentrated under reduced pressure, and the obtained residue was suspended in diisopropyl ether. The suspension was filtered to give the title compound as white crystals (291 mg, 1.33 mmol, 75%).

後処理

  1. concentrationthe reaction mixture was concentrated under reduced pressure
  2. filtrationThe suspension was filtered

出典と根拠

ORDレコード
ord-b64c9b6861254997bd7f20929fefe32b
出典データセット
uspto-grants-2015_08
特許番号
US09115107B2

関連ノート

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