Hydrochloric Acid → N-allyl-L-aspartic acid di-tert-butyl ester hydrochloride

HRID 517361ノート

反応式

HRID 517361 の反応式
[C:1]([O:5][C:6](=[O:20])[C@H:7]([CH2:12][C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[NH:8][CH2:9][CH:10]=[CH2:11])([CH3:4])([CH3:3])[CH3:2].O.[ClH:22]>C(#N)C>[ClH:22].[C:1]([O:5][C:6](=[O:20])[C@H:7]([CH2:12][C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[NH:8][CH2:9][CH:10]=[CH2:11])([CH3:4])([CH3:2])[CH3:3]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 86673330N-allyl-L-aspartic acid di-tert-butyl ester

生成物 1

HCID 86673331N-allyl-L-aspartic acid di-tert-butyl ester hydrochloride収率 47%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

The obtained N-allyl-L-aspartic acid di-tert-butyl ester was dissolved in acetonitrile (10 mL), and water (17 mL) and 1N hydrochloric acid (1.8 mL, 1.8 mmol) were added. The solution was concentrated under reduced pressure and freeze-dried to give the title compound (0.54 g, 1.7 mmol, 47%).

後処理

  1. concentrationThe solution was concentrated under reduced pressure
  2. customfreeze-dried

出典と根拠

ORDレコード
ord-889097096d9840028c8fd821287ab804
出典データセット
uspto-grants-2015_08
特許番号
US09115107B2

反応ノート

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