Sulfuric Acid → 1H-Indole-2,3-dione, 6-bromo-
反応式
S(=O)(=O)(O)[OH:2].[Br:6][C:7]1[CH:8]=[C:9]([NH:13][C:14](=[O:18])[CH:15]=NO)[CH:10]=[CH:11][CH:12]=1>>[Br:6][C:7]1[CH:8]=[C:9]2[C:10]([C:15](=[O:2])[C:14](=[O:18])[NH:13]2)=[CH:11][CH:12]=1参加物
3
反応条件
- 温度
- 90 °C
実験手順
To the concentrated sulfuric acid (275 mL) at 50° C. was added N-(3-Bromo-phenyl)-2-hydroxyimino-acetamide (55 g, 0.2272 mol). The temperature was raised to 90° C. and maintained for 3 h. The reaction mixture was added to ice cold water to get yellow precipitate. The precipitate was filtered and dried to get the title compound as a yellow solid [50 g, 98%]. This material was taken to the next step without any further purification.
後処理
- temperaturemaintained for 3 h
- additionThe reaction mixture was added to ice cold water
- customto get yellow precipitate
- filtrationThe precipitate was filtered
- customdried
出典と根拠
- ORDレコード
- ord-097cadf1ee1e402d8af8573733d12e98
- 出典データセット
- uspto-grants-2015_08
- 特許番号
- US09115092B2
反応ノート
読み込み中…