Sulfuric Acid → 1H-Indole-2,3-dione, 6-bromo-

HRID 517435

反応式

HRID 517435 の反応式
S(=O)(=O)(O)[OH:2].[Br:6][C:7]1[CH:8]=[C:9]([NH:13][C:14](=[O:18])[CH:15]=NO)[CH:10]=[CH:11][CH:12]=1>>[Br:6][C:7]1[CH:8]=[C:9]2[C:10]([C:15](=[O:2])[C:14](=[O:18])[NH:13]2)=[CH:11][CH:12]=1

参加物

3

反応物 2

HCID 1118Sulfuric AcidHCID 6739944Acetamide, N-(3-bromophenyl)-2-(hydroxyimino)-

生成物 1

HCID 957161H-Indole-2,3-dione, 6-bromo-収率 98%

反応条件

温度
90 °C

実験手順

To the concentrated sulfuric acid (275 mL) at 50° C. was added N-(3-Bromo-phenyl)-2-hydroxyimino-acetamide (55 g, 0.2272 mol). The temperature was raised to 90° C. and maintained for 3 h. The reaction mixture was added to ice cold water to get yellow precipitate. The precipitate was filtered and dried to get the title compound as a yellow solid [50 g, 98%]. This material was taken to the next step without any further purification.

後処理

  1. temperaturemaintained for 3 h
  2. additionThe reaction mixture was added to ice cold water
  3. customto get yellow precipitate
  4. filtrationThe precipitate was filtered
  5. customdried

出典と根拠

ORDレコード
ord-097cadf1ee1e402d8af8573733d12e98
出典データセット
uspto-grants-2015_08
特許番号
US09115092B2

関連ノート

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