Sodium Hydroxide → 9-(6-Oxo-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)nonanoic acid

HRID 517896

反応式

HRID 517896 の反応式
[O:1]=[C:2]1[N:25]([CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][C:34]([O:36]CC)=[O:35])[C:6]2=[N:7][C:8]([C:18]3[CH:23]=[CH:22][C:21]([CH3:24])=[CH:20][CH:19]=3)=[C:9]([C:11]3[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][CH:12]=3)[N:10]=[C:5]2[CH2:4][CH2:3]1.[OH-].[Na+]>CO>[O:1]=[C:2]1[N:25]([CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][C:34]([OH:36])=[O:35])[C:6]2=[N:7][C:8]([C:18]3[CH:23]=[CH:22][C:21]([CH3:24])=[CH:20][CH:19]=3)=[C:9]([C:11]3[CH:12]=[CH:13][C:14]([CH3:17])=[CH:15][CH:16]=3)[N:10]=[C:5]2[CH2:4][CH2:3]1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 89690004Ethyl 9-(6-oxo-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)nonanoate

生成物 1

HCID 716576499-(6-Oxo-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)nonanoic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of ethyl 9-(6-oxo-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)nonanoate (step 1)(392.5 mg, 0.764 mmol) in MeOH (10 ml) was treated with 1M NaOH (2.292 ml, 2.292 mmol) and stirred at RT overnight. The mixture was concentrated under reduced pressure to remove MeOH and acidified using 1M HCl. The resulting mixture was extracted with DCM and the organic extracts were concentrated under reduced pressure to afford the titled compound;

後処理

  1. concentrationThe mixture was concentrated under reduced pressure
  2. customto remove MeOH
  3. extractionThe resulting mixture was extracted with DCM
  4. concentrationthe organic extracts were concentrated under reduced pressure

出典と根拠

ORDレコード
ord-2eb6fab97ede45a7b5e7b73b3b349151
出典データセット
uspto-grants-2015_08
特許番号
US09115129B2

関連ノート

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