5'-Bromo-2'-hydroxyacetophenone → 1'-Phenyl-6-bromo-spiro[chromane-2,4'-piperidine]-4-one

HRID 518173

反応式

HRID 518173 の反応式
COC(=O)/C=C/C1C=C2C(=CC=1)OC1(CCN(C(OC(C)(C)C)=O)CC1)CC2=O.[C:30]1([N:36]2[CH2:41][CH2:40][C:39](=[O:42])[CH2:38][CH2:37]2)[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1.[CH3:43][C:44]([C:46]1[CH:51]=[C:50]([Br:52])[CH:49]=[CH:48][C:47]=1O)=[O:45]>>[C:30]1([N:36]2[CH2:37][CH2:38][C:39]3([CH2:43][C:44](=[O:45])[C:46]4[C:47](=[CH:48][CH:49]=[C:50]([Br:52])[CH:51]=4)[O:42]3)[CH2:40][CH2:41]2)[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1

参加物

4

反応物 3

HCID 959915'-Bromo-2'-hydroxyacetophenoneHCID 4130091-Phenyl-4-piperidinoneHCID 52952087(E)-3-{1'-tert-butoxycarbonyl-4-oxo-spiro[chromane-2,4'-piperidine]-6-yl}-acrylic acid methyl ester

生成物 1

HCID 669322201'-Phenyl-6-bromo-spiro[chromane-2,4'-piperidine]-4-one

実験手順

1′-Phenyl-6-bromo-spiro[chromane-2,4′-piperidine]-4-one was synthesized according to the procedure for preparation of Intermediate 1, Step A, using 1-phenyl-piperidin-4-one (607 mg, 3.47 mmol) and 2-hydroxy-5-bromoacetophenone (746 mg, 3.47 mmol), giving 650 mg as a white solid.

後処理

  1. customgiving 650 mg as a white solid

出典と根拠

ORDレコード
ord-c0950ea8371547d0926ea53da7c061be
出典データセット
uspto-grants-2015_08
特許番号
US09115148B2

関連ノート

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