(2-Methoxy-ethyl)-(4-methoxy-3-nitro-phenyl)-methyl-amine → 4-methoxy-N1-(2-methoxy-ethyl)-N1-methyl-benzene-1,3-diamine
反応式
[CH3:1][O:2][CH2:3][CH2:4][N:5]([C:7]1[CH:12]=[CH:11][C:10]([O:13][CH3:14])=[C:9]([N+:15]([O-])=O)[CH:8]=1)[CH3:6]>CO.[Pd]>[CH3:14][O:13][C:10]1[CH:11]=[CH:12][C:7]([N:5]([CH2:4][CH2:3][O:2][CH3:1])[CH3:6])=[CH:8][C:9]=1[NH2:15]参加物
4
実験手順
To a stirred solution of 2.50 g (10.4 mmol) (2-methoxy-ethyl)-(4-methoxy-3-nitro-phenyl)-methyl-amine in 100 ml methanol was added a spatula end of 10% palladium on charcoal and the mixture was then stirred for 16 hours at room temperature under an atmosphere of hydrogen. The mixture was then filtered and the filtrate concentrated in vacuo to afford 1.90 g (87 (ho) 4-methoxy-N1-(2-methoxy-ethyl)-N1-methyl-benzene-1,3-diamine as an off-white crystalline solid. ES-MS m/e (%): 211 (M+H+, 100).
後処理
- filtrationThe mixture was then filtered
- concentrationthe filtrate concentrated in vacuo
出典と根拠
- ORDレコード
- ord-d8b1b0948c6d4cfbb28598808defdb52
- 出典データセット
- uspto-grants-2004_03
- 特許番号
- US06713499B2
反応ノート
読み込み中…