Methanol → HCID 178457841、化合物

関与物質

反応手順

A suspension of cis-4-(2-chloro-5-nitropyridin-4-ylamino)-N-isopropylcyclohexanecarboxamide (0.200 g, 0.587 mmol) and 2-(piperidin-4-yl)propan-2-ol (0.420 g, 2.93 mmol) in 2-propanol (2.003 mL) was microwave irradiated for 1 hour at 150° C. The reaction mixture was concentrated in vacuo, and the residual material was purified via silica gel chromatography eluting with isocratic 90:10:1 DCM:MeOH:NH4OH, to provide cis-4-(2-(4-(2-hydroxypropan-2-yl)piperidin-1-yl)-5-nitropyridin-4-ylamino)-N-isopropylcyclohexanecarboxamide as a yellow solid (0.263 g, 100% yield). MS m/z=448.2 [M+H], calc 447.57 for C23H37FN5O4.

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