反应详情

A suspension of cis-4-(2-chloro-5-nitropyridin-4-ylamino)-N-isopropylcyclohexanecarboxamide (0.200 g, 0.587 mmol) and 2-(piperidin-4-yl)propan-2-ol (0.420 g, 2.93 mmol) in 2-propanol (2.003 mL) was microwave irradiated for 1 hour at 150° C. The reaction mixture was concentrated in vacuo, and the residual material was purified via silica gel chromatography eluting with isocratic 90:10:1 DCM:MeOH:NH4OH, to provide cis-4-(2-(4-(2-hydroxypropan-2-yl)piperidin-1-yl)-5-nitropyridin-4-ylamino)-N-isopropylcyclohexanecarboxamide as a yellow solid (0.263 g, 100% yield). MS m/z=448.2 [M+H], calc 447.57 for C23H37FN5O4.

1. customwas microwave irradiated for 1 hour at 150° C
2. concentrationThe reaction mixture was concentrated in vacuo
3. customthe residual material was purified via silica gel chromatography
4. washeluting with isocratic 90:10:1 DCM