[CH:1]([CH:3]1[CH2:8][CH2:7][N:6]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH2:5][CH2:4]1)=O.[F:16][C:17]([F:21])([F:20])[CH2:18][NH2:19].C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+].[OH-].[Na+]>C(Cl)Cl.C([O-])(O)=O.[Na+].CC(O)=O>[F:16][C:17]([F:21])([F:20])[CH2:18][NH:19][CH2:1][CH:3]1[CH2:8][CH2:7][N:6]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH2:5][CH2:4]1
To a solution of tert-butyl 4-formylpiperidine-1-carboxylate (1 g, 4.69 mmol) in DCM (25 mL) was added 2,2,2-trifluoroethanamine (0.464 g, 4.69 mmol) and AcOH (0.05 mL). The reaction was stirred at RT for 3 hours and then sodium triacetoxyborohydride (1.292 g, 6.10 mmol) was added, and the reaction was stirred at RT for 16 hours. The reaction was diluted with DCM and saturated aqueous NaHCO3. The aqueous layer was adjusted to a pH of approximately 10 with 1 N aqueous NaOH, and extracted with DCM. The combined organic layers were dried over anhydrous magnesium sulfate, filtered, and concentrated to generate tert-butyl 4-((2,2,2-trifluoroethylamino)methyl)piperidine-1-carboxylate as a colorless oil (1.49 g, 107% yield).
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