化工社化工社 化学情報印刷レポート · 研究参考用
Acetyl chloride → N-{7-[Acetyl-(2-methoxy-ethyl)-amino]-4-methoxy-benzothiazol-2-yl}-2-bromo-isonicotinamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetyl chloride | HCID 6367 | — |
| 反応物 | 4-Methylmorpholine | HCID 7972 | — |
| 反応物 | 2-Bromoisonicotinic acid | HCID 222701 | — |
| 反応物 | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| 反応物 | 4-methoxy-N7-(2-methoxy-ethyl)-benzothiazole-2,7-diamine | HCID 22736980 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | N-{7-[Acetyl-(2-methoxy-ethyl)-amino]-4-methoxy-benzothiazol-2-yl}-2-bromo-isonicotinamide | HCID 22736982 | — |
反応手順
From 4-methoxy-N7-(2-methoxy-ethyl)-benzothiazole-2,7-diamine with pyridine and acetyl chloride in dichloromethane and THF, then treatment with 2-bromo-isonicotinic acid, HATU and N-methylmopholine in THF. ES-MS m/e (%): 481 (M{81Br}+H+, 100), 479 (M{79Br}+H+, 99).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06713499B2 |
| 出典データセット | uspto-grants-2004_03 |
| ORD ID | ord-81866feb449a4ab48a3efda43d9b29dc |
| 出典メモ | uspto-grants-2004_03 |