HCID 22736995、化合物 → HCID 22736961、化合物
反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]([CH3:17])[CH2:10][CH:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)=[CH:5][C:4]=1[N+:18]([O-])=O>CO.[Pd]>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]([CH3:17])[CH2:10][CH:11]2[CH2:12][CH2:13][O:14][CH2:15][CH2:16]2)=[CH:5][C:4]=1[NH2:18]参加物
4
実験手順
To a stirred solution of 3.5 g (12.5 mmol) (4-methoxy-3-nitro-phenyl)-methyl-(tetrahydro-pyran-4-ylmethyl)-amine in 230 ml methanol was added 70 mg 10% palladium on charcoal and the mixture was then stirred for 18 hours at room temperature under an atmosphere of hydrogen. The mixture was then filtered and the filtrate concentrated in vacuo to afford 2.20 g (70%) 4-methoxy-N1-methyl-N1-(tetrahydropyran-4-ylmethyl)-benzene-1,3-diamine as a dark brown oil. ES-MS m/e (%): 251 (M+H+, 100).
後処理
- filtrationThe mixture was then filtered
- concentrationthe filtrate concentrated in vacuo
出典と根拠
- ORDレコード
- ord-f38179065dd642c597e1d36ca259032e
- 出典データセット
- uspto-grants-2004_03
- 特許番号
- US06713499B2
反応ノート
読み込み中…