Dimethylformamide → 4-Bromo-2-fluorobenzoyl chloride

HRID 520311ノート

反応式

HRID 520311 の反応式
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](O)=[O:7])=[C:4]([F:11])[CH:3]=1.C(Cl)(=O)C([Cl:15])=O.CN(C=O)C>C(Cl)Cl>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([Cl:15])=[O:7])=[C:4]([F:11])[CH:3]=1

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 3026814-Bromo-2-fluorobenzoic acid

生成物 1

HCID 27340264-Bromo-2-fluorobenzoyl chloride収率 100.1%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 4-bromo-2-fluorobenzoic acid 144a (250 g, 1.14 mol) in dry DCM (2000 mL) was added oxalyl chloride (446 g, 3.51 mol) and DMF (10 mL) at RT, and the reaction mixture was stirred at RT for 1 h. See FIG. 3. The mixture was concentrated under reduced pressure to give 4-bromo-2-fluorobenzoyl chloride 144b (271 g, 100%) as a yellow solid, which was used for the next step without further purification.

後処理

  1. concentrationThe mixture was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-54e8f043908945eba44edd67a3401a95
出典データセット
uspto-grants-2016_05
特許番号
US09326985B2

反応ノート

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