m-Toluidine → 4-(3'-Methylanilino)-7-nitroquinazoline

HRID 52033

反応式

HRID 52033 の反応式
[N+](C1C=C(N)C(=CC=1)C(O)=O)([O-])=O.Cl[C:15]1[C:24]2[C:19](=[CH:20][C:21]([N+:25]([O-:27])=[O:26])=[CH:22][CH:23]=2)[N:18]=[CH:17][N:16]=1.[CH3:28][C:29]1[CH:30]=[C:31]([CH:33]=[CH:34][CH:35]=1)[NH2:32]>>[CH3:28][C:29]1[CH:30]=[C:31]([CH:33]=[CH:34][CH:35]=1)[NH:32][C:15]1[C:24]2[C:19](=[CH:20][C:21]([N+:25]([O-:27])=[O:26])=[CH:22][CH:23]=2)[N:18]=[CH:17][N:16]=1

参加物

4

反応物 3

HCID 7934m-ToluidineHCID 120764-Nitroanthranilic acidHCID 8306804-Chloro-7-nitroquinazoline2 回

生成物 1

HCID 199631924-(3'-Methylanilino)-7-nitroquinazoline

実験手順

Using an analogous procedure to that described in the portion of Example 1 which is concerned with the preparation of starting materials, 4-nitroanthranilic acid was converted into 4-chloro-7-nitroquinazoline. Using an analogous procedure to that described in Example 1 except that the reactants were stirred together at ambient temperature for 20 minutes, 4-chloro-7-nitroquinazoline was reacted with 3-methylaniline to give 4-(3'-methylanilino)-7-nitroquinazoline.

出典と根拠

ORDレコード
ord-16340ac8250848558fcbc5b79456313e
出典データセット
uspto-grants-1997_04
特許番号
US05616582

関連ノート

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