Phenyltrimethylammonium bromide dibromide → 2-Bromo-1-(4-bromo-2-methylphenyl)ethanone
反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[C:4]([CH3:11])[CH:3]=1.[Br-:12].[Br-].[Br-].C1([N+](C)(C)C)C=CC=CC=1.C1([N+](C)(C)C)C=CC=CC=1.C1([N+](C)(C)C)C=CC=CC=1>C1COCC1>[Br:12][CH2:9][C:8]([C:5]1[CH:6]=[CH:7][C:2]([Br:1])=[CH:3][C:4]=1[CH3:11])=[O:10]参加物
4
実験手順
To a solution of 1-(4-bromo-2-methylphenyl)ethanone (0.525 g, 2.464 mmol) in THF was added phenyltrimethylammonium tribromide (0.926 g, 2.464 mmol). The reaction mixture was stirred at rt for 16 hrs. The reaction mixture was filtered through a plug of diatomaceous earth (Celite®), and the filtrate was concentrated to yield 2-bromo-1-(4-bromo-2-methylphenyl)-ethanone (0.61 g) as a white solid. LC/MS (Cond. N-1): [M+H]+ 290.84, Rt=3.88 min.
後処理
- filtrationThe reaction mixture was filtered through a plug of diatomaceous earth (Celite®)
- concentrationthe filtrate was concentrated
出典と根拠
- ORDレコード
- ord-2eb17bfbea9e48c7a7405678ca258b86
- 出典データセット
- uspto-grants-2016_05
- 特許番号
- US09326973B2
反応ノート
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