Benzyl 3,3-difluoro-2,2-dimethylpropanoate → 3,3-Difluoro-2,2-dimethylpropanoic acid

HRID 520372ノート

反応式

HRID 520372 の反応式
[F:1][CH:2]([F:16])[C:3]([CH3:15])([CH3:14])[C:4]([O:6]CC1C=CC=CC=1)=[O:5]>CCOC(C)=O.[Pd]>[F:1][CH:2]([F:16])[C:3]([CH3:15])([CH3:14])[C:4]([OH:6])=[O:5]

参加物

4

反応物 1

HCID 86690093Benzyl 3,3-difluoro-2,2-dimethylpropanoate

生成物 1

HCID 198673873,3-Difluoro-2,2-dimethylpropanoic acid収率 99.6%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

A stirred suspension of benzyl 3,3-difluoro-2,2-dimethylpropanoate (340 mg, 1.49 mmol) and 10% Pd—C (42 mg, 0.04 mmol) in EtOAc (20 mL) was hydrogenated under balloon pressure overnight. The suspension was filtered and the filtrate was evaporated to dryness to afford Cap-11 as a white solid (205 mg). 1H NMR (400 MHz, chloroform-d) δ 6.01 (t, J=1.0 Hz, 1H), 2.07 (br. s, 1H), 1.34 (t, J=1.0 Hz, 6H).

後処理

  1. customwas hydrogenated under balloon pressure overnight
  2. filtrationThe suspension was filtered
  3. customthe filtrate was evaporated to dryness

出典と根拠

ORDレコード
ord-cc61402c183b4a5bbfc890def0dc2fca
出典データセット
uspto-grants-2016_05
特許番号
US09326973B2

反応ノート

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