HCID 86690121、化合物 → Methyl 2-(hydroxymethyl)tetrahydrofuran-2-carboxylate

HRID 520416ノート

反応式

HRID 520416 の反応式
C([O:8][CH2:9][C:10]1([C:15]([O:17][CH3:18])=[O:16])[CH2:14][CH2:13][CH2:12][O:11]1)C1C=CC=CC=1>CO.[Pd]>[OH:8][CH2:9][C:10]1([C:15]([O:17][CH3:18])=[O:16])[CH2:14][CH2:13][CH2:12][O:11]1

参加物

4

反応物 1

HCID 86690121HCID 86690121、化合物

生成物 1

HCID 86690120Methyl 2-(hydroxymethyl)tetrahydrofuran-2-carboxylate収率 178.3%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

10% Pd—C (80 mg, 0.753 mmol) was added under nitrogen to a solution of methyl 2-((benzyloxy)methyl)tetrahydrofuran-2-carboxylate (377 mg, 1.506 mmol) in MeOH (20 mL) in a Parr shaker bottle and hydrogenated at 30 psi overnight. The suspension was filtered and the filtrate was evaporated to dryness to afford methyl 2-(hydroxymethyl)tetrahydrofuran-2-carboxylate as a clear oil (0.43 g, 97.5%). 1H NMR (500 MHz, CHLOROFORM-d) δ ppm 4.10-3.98 (m, 2H), 3.85 (d, J=11.4 Hz, 1H), 3.78 (s, 3H), 3.69 (d, J=11.4 Hz, 1H), 2.19-2.12 (m, 1H), 2.09-2.02 (m, 1H), 2.01-1.93 (m, 2H).

後処理

  1. filtrationThe suspension was filtered
  2. customthe filtrate was evaporated to dryness

出典と根拠

ORDレコード
ord-dcac1a5f3a5a49f69855bab980695c17
出典データセット
uspto-grants-2016_05
特許番号
US09326973B2

反応ノート

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