Potassium methoxide → Methyl thiane-2-carboxylate
反応式
C[O-].[K+].C([S:7][CH:8]([CH2:13][CH2:14][CH2:15][CH2:16]Br)[C:9]([O:11][CH3:12])=[O:10])(=O)C>C1COCC1>[S:7]1[CH2:16][CH2:15][CH2:14][CH2:13][CH:8]1[C:9]([O:11][CH3:12])=[O:10]参加物
4
実験手順
Neat potassium methoxide (133 mg, 1.893 mmol) was added to a solution of methyl 2-(acetylthio)-6-bromohexanoate (536 mg, 1.893 mmol) in an. THF (18 mL) and the mixture was stirred at rt for 2 days under nitrogen. The crude isolate was purified by silica gel FCC (DCM) to afford methyl tetrahydro-2H-thiopyran-2-carboxylate as a clear oil which was saponified (1N NaOH, MeOH-THF) to afford Cap P-38.
後処理
- customThe crude isolate
- customwas purified by silica gel FCC (DCM)
出典と根拠
- ORDレコード
- ord-daf36efc5a1d4177bfabaf8b77290dd4
- 出典データセット
- uspto-grants-2016_05
- 特許番号
- US09326973B2
反応ノート
読み込み中…