Water → 8-nitro-2-(3-(trifluoromethyl)phenyl)-4H-benzo[d][1,3]oxazin-4-one

HRID 520436ノート

反応式

HRID 520436 の反応式
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][CH:11]=1)[C:6](Cl)=[O:7].[NH2:14][C:15]1[C:23]([N+:24]([O-:26])=[O:25])=[CH:22][CH:21]=[CH:20][C:16]=1[C:17](O)=[O:18].O>N1C=CC=CC=1>[N+:24]([C:23]1[C:15]2[N:14]=[C:6]([C:5]3[CH:9]=[CH:10][CH:11]=[C:3]([C:2]([F:13])([F:12])[F:1])[CH:4]=3)[O:7][C:17](=[O:18])[C:16]=2[CH:20]=[CH:21][CH:22]=1)([O-:26])=[O:25]

参加物

5

反応物 3

HCID 962WaterHCID 752573-(Trifluoromethyl)benzoyl chlorideHCID 2196332-Amino-3-nitrobenzoic acid

生成物 1

HCID 585528458-nitro-2-(3-(trifluoromethyl)phenyl)-4H-benzo[d][1,3]oxazin-4-one収率 54.1%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

3-(trifluoromethyl)benzoyl chloride 2 (4.5 mL, 30.2 mmol) was added to a suspension of 2-amino-3-nitrobenzoic acid 1 (5.0 g, 27.5 mmol) in pyridine (65 mL). The reaction mixture was stirred at room temperature for 12 h then poured into ice cooled H2O (300 mL). The resulting precipitate was collected by filtration, rinsed with H2O, and dried under vacuum to give 3 (5 g, 51% yield) as a yellow solid which was used without further purification.

後処理

  1. additionthen poured into ice
  2. filtrationThe resulting precipitate was collected by filtration
  3. washrinsed with H2O
  4. customdried under vacuum

出典と根拠

ORDレコード
ord-d9cc5416c88d4659bce75138ee3a524c
出典データセット
uspto-grants-2016_05
特許番号
US09326986B2

反応ノート

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