Hydrochloric Acid → 2-(difluoromethyl)benzoic Acid
反応式
[F:1][CH:2]([F:13])[C:3]1[CH:12]=[CH:11][CH:10]=[CH:9][C:4]=1[C:5]([O:7]C)=[O:6].[OH-].[Na+].Cl>CO>[F:1][CH:2]([F:13])[C:3]1[CH:12]=[CH:11][CH:10]=[CH:9][C:4]=1[C:5]([OH:7])=[O:6]参加物
5
実験手順
A mixture of methyl 2-(difluoromethyl)benzoate 52 (7 g, 38 mmol) and 10% aq. NaOH (100 mL) in MeOH (50 mL) was heated at reflux for 30 min. The pH was adjusted to 4 by the addition of 3N HCl. The resulting solid was collected by filtration, rinsed with H2O and dried to give 53 (6 g, 93% yield).
後処理
- temperaturewas heated
- temperatureat reflux for 30 min
- filtrationThe resulting solid was collected by filtration
- washrinsed with H2O
- customdried
出典と根拠
- ORDレコード
- ord-3140ad8e436a4c06bf35fe024b0e4793
- 出典データセット
- uspto-grants-2016_05
- 特許番号
- US09326986B2
反応ノート
読み込み中…