Trifluoroacetic acid → HCID 86660237、化合物

HRID 520489ノート

反応式

HRID 520489 の反応式
[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][C:8]2[N:9]=[C:10]([NH:13]C(=O)OC(C)(C)C)[S:11][CH:12]=2)[CH2:3][CH2:2]1.[F:21][C:22]([F:27])([F:26])[C:23]([OH:25])=[O:24]>C(Cl)Cl>[F:21][C:22]([F:27])([F:26])[C:23]([OH:25])=[O:24].[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][C:8]2[N:9]=[C:10]([NH2:13])[S:11][CH:12]=2)[CH2:3][CH2:2]1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 58154672Tert-butyl 4-(morpholinomethyl)thiazol-2-ylcarbamate

生成物 1

HCID 86660237HCID 86660237、化合物収率 100%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Tert-butyl 4-(morpholinomethyl)thiazol-2-ylcarbamate 90 (1.88 g, 6.28 mmol) was treated with 20 mL of 25% trifluoroacetic acid in CH2Cl2 for 18 h at room temperature. After all the solvent had been removed by concentrating and drying under high vacuum, the resulting residue was treated with a mixture of pentane/EtOAc to afford 91 (1.96 g, 100% yield) as a white solid.

後処理

  1. customAfter all the solvent had been removed
  2. concentrationby concentrating
  3. customdrying under high vacuum
  4. additionthe resulting residue was treated with a mixture of pentane/EtOAc

出典と根拠

ORDレコード
ord-7b49e0f97b4b4b0fb5a69cde5d0a513a
出典データセット
uspto-grants-2016_05
特許番号
US09326986B2

反応ノート

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