Hydrochloric Acid → 4-bromo-2-chloro-1H-indole

HRID 520599ノート

反応式

HRID 520599 の反応式
[Br:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([Cl:21])[N:6]2S(C1C=CC(C)=CC=1)(=O)=O.[OH-].[Na+].Cl>CC(O)C>[Br:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([Cl:21])[NH:6]2

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 682264944-Bromo-2-chloro-1-[(4-methylphenyl)sulfonyl]-1H-indole

生成物 1

HCID 197003094-bromo-2-chloro-1H-indole

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

反応条件

温度
120 °C

実験手順

4-Bromo-2-chloro-1-[(4-methylphenyl)sulfonyl]-1H-indole (215 mg), IPA (2.5 ml) and 2 M NaOH (aq) (2.5 ml) were mixed in a microwave vial and heated in the microwave for 30 min at 120° C. The reaction was acidified using 2M HCl (aq) and then extracted with DCM, which was passed through a hydrophobic frit, then evaporated to dryness. The residue was triturated with methanol which was then evaporated to afford the title compound, 112 mg.

後処理

  1. extractionextracted with DCM, which
  2. customevaporated to dryness
  3. customThe residue was triturated with methanol which
  4. customwas then evaporated

出典と根拠

ORDレコード
ord-d646c431cbbf481e812a3bc780829b0b
出典データセット
uspto-grants-2016_05
特許番号
US09326987B2

反応ノート

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