Hydrochloric Acid → 6-(1H-Indol-4-yl)-4-[5-(4-morpholinylmethyl)-1,3,4-oxadiazol-2-yl]-1H-indazole

HRID 520609ノート

反応式

HRID 520609 の反応式
[NH:1]1[C:9]2[C:4](=[C:5]([C:10]3[CH:18]=[C:17]4[C:13]([CH:14]=[N:15][N:16]4S(C4C=CC(C)=CC=4)(=O)=O)=[C:12]([C:29]4[O:30][C:31]([CH2:34][N:35]5[CH2:40][CH2:39][O:38][CH2:37][CH2:36]5)=[N:32][N:33]=4)[CH:11]=3)[CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.[OH-].[Na+].Cl>C(O)(C)C>[NH:1]1[C:9]2[C:4](=[C:5]([C:10]3[CH:18]=[C:17]4[C:13]([CH:14]=[N:15][NH:16]4)=[C:12]([C:29]4[O:30][C:31]([CH2:34][N:35]5[CH2:40][CH2:39][O:38][CH2:37][CH2:36]5)=[N:32][N:33]=4)[CH:11]=3)[CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 667766026-(1H-Indol-4-yl)-1-[(4-methylphenyl)sulfonyl]-4-[5-(4-morpholinylmethyl)-1,3,4-oxadiazol-2-yl]-1H-indazole

生成物 1

HCID 468925236-(1H-Indol-4-yl)-4-[5-(4-morpholinylmethyl)-1,3,4-oxadiazol-2-yl]-1H-indazole

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

A stirred solution of 6-(1H-indol-4-yl)-1-[(4-methylphenyl)sulfonyl]-4-[5-(4-morpholinylmethyl)-1,3,4-oxadiazol-2-yl]-1H-indazole (25 mg, 0.045 mmol) and 2M sodium hydroxide (3 ml) in isopropanol (10 ml) was stirred at room temperature for 1 h. The solution was treated with 2M hydrochloric acid (3 ml) and evaporated to low bulk until the product was precipitated. The resulting solid was collected by filtration and washed with water to give the title compound as a cream coloured solid (15 mg).

後処理

  1. customevaporated to low bulk until the product
  2. customwas precipitated
  3. filtrationThe resulting solid was collected by filtration
  4. washwashed with water

出典と根拠

ORDレコード
ord-56cf25ee45a04c328056aa5ded73623d
出典データセット
uspto-grants-2016_05
特許番号
US09326987B2

反応ノート

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