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Sodium Hydroxide → N-[5-(4-{5-[(8aS)-Hexahydropyrrolo[1,2-a]pyrazin-2(1H)-ylmethyl]-1,3,4-oxadiazol-2-yl}-1H-indazol-6-yl)-2-(methyloxy)-3-pyridinyl]methanesulfonamide

HRID 520638
ノート
印刷プレビュー

反応式

HRID 520638 の反応式
[CH2:1]1[N:6]([CH2:7][C:8]2[O:12][C:11]([C:13]3[CH:21]=[C:20]([C:22]4[CH:23]=[C:24]([NH:30][S:31]([CH3:34])(=[O:33])=[O:32])[C:25]([O:28][CH3:29])=[N:26][CH:27]=4)[CH:19]=[C:18]4[C:14]=3[CH:15]=[N:16][N:17]4S(C3C=CC=CC=3)(=O)=O)=[N:10][N:9]=2)[CH2:5][CH2:4][N:3]2[CH2:44][CH2:45][CH2:46][C@@H:2]12.[OH-].[Na+]>O1CCOCC1>[CH2:1]1[N:6]([CH2:7][C:8]2[O:12][C:11]([C:13]3[CH:21]=[C:20]([C:22]4[CH:23]=[C:24]([NH:30][S:31]([CH3:34])(=[O:32])=[O:33])[C:25]([O:28][CH3:29])=[N:26][CH:27]=4)[CH:19]=[C:18]4[C:14]=3[CH:15]=[N:16][NH:17]4)=[N:10][N:9]=2)[CH2:5][CH2:4][N:3]2[CH2:44][CH2:45][CH2:46][C@@H:2]12
参加物実験手順後処理出典と根拠反応ノート

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 66693044N-[5-[4-{5-[(8aS)-Hexahydropyrrolo[1,2-a]pyrazin-2(1H)-ylmethyl]-1,3,4-oxadiazol-2-yl}-1-(phenylsulfonyl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]methanesulfonamide

生成物 1

HCID 66695909N-[5-(4-{5-[(8aS)-Hexahydropyrrolo[1,2-a]pyrazin-2(1H)-ylmethyl]-1,3,4-oxadiazol-2-yl}-1H-indazol-6-yl)-2-(methyloxy)-3-pyridinyl]methanesulfonamide収率 34.7%

試薬・触媒・溶媒 1

HCID 31275
1,4-Dioxane
溶媒

実験手順

N-[5-[4-{5-[(8aS)-Hexahydropyrrolo[1,2-a]pyrazin-2(1H)-ylmethyl]-1,3,4-oxadiazol-2-yl}-1-(phenylsulfonyl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]methanesulfonamide (95 mg, 0.143 mmol) was dissolved in 1,4-dioxane (1 ml) and sodium hydroxide (1 ml, 0.143 mmol) was added. The mixture was stirred at room temperature for 1 h. The mixture was dried down under a stream of nitrogen and the residue partitioned between ethyl acetate (5 ml) and saturated ammonium chloride (2 ml). The organic layer was separated, dried by passing through a hydrophobic frit and the solvent removed in vacuo to give an orange oil. This was triturated with cyclohexane to give the title compound as an orange solid (26 mg).

後処理

  1. customThe mixture was dried down under a stream of nitrogen
  2. customthe residue partitioned between ethyl acetate (5 ml) and saturated ammonium chloride (2 ml)
  3. customThe organic layer was separated
  4. customdried
  5. customthe solvent removed in vacuo
  6. customto give an orange oil
  7. customThis was triturated with cyclohexane

出典と根拠

ORDレコード
ord-393e559a52414060acb1256414a21503
出典データセット
uspto-grants-2016_05
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US09326987B2

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート