Dimethylformamide → Acetyl chloride, (4-cyanophenoxy)-

HRID 520833ノート

反応式

HRID 520833 の反応式
[C:1]([C:3]1[CH:13]=[CH:12][C:6]([O:7][CH2:8][C:9](O)=[O:10])=[CH:5][CH:4]=1)#[N:2].C(Cl)(=O)C([Cl:17])=O.CN(C)C=O>ClCCl>[C:1]([C:3]1[CH:13]=[CH:12][C:6]([O:7][CH2:8][C:9]([Cl:17])=[O:10])=[CH:5][CH:4]=1)#[N:2]

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 7360972-(4-Cyanophenoxy)acetic acid

生成物 1

HCID 12207748Acetyl chloride, (4-cyanophenoxy)-

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

To a suspension of commercially available 2-(4-cyanophenoxy)acetic acid (4.0 g, 22.6 mmol) in dichloromethane (80 mL) was added oxalyl chloride (2.17 mL, 24.8 mmol). To this mixture was added N,N-dimethylformamide (30 μL) dropwise and the mixture was stirred for 2 hours during which cessation of evolution of gas was observed. The resulting solution was diluted with dichloromethane (50 mL) and the solvent was removed under reduced pressure to provide the title compound as an oil which became a solid upon storing in the refrigerator.

後処理

  1. customthe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-00020fe290904569b680f086c2c5b012
出典データセット
uspto-grants-2016_05
特許番号
US09328095B2

反応ノート

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