2-(2-Hydroxyethyl)pyridine → 2-(2-Chloroethyl)pyridine

HRID 520874

反応式

HRID 520874 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH2:8]O.O=S(Cl)[Cl:12]>C(Cl)Cl>[Cl:12][CH2:8][CH2:7][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=1

参加物

4

反応物 2

HCID 76752-(2-Hydroxyethyl)pyridineHCID 24386Thionyl Chloride

生成物 1

HCID 1994682-(2-Chloroethyl)pyridine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

2-(Pyridin-2-yl)ethanol (1 g, 8.12 mmol) was first treated with SOCl2 (3 ml) in CH2Cl2 (10 ml) at rt for 3 hrs. The solvent was removed to get a crude 2-(2-chloroethyl)pyridine. Then following General Procedure A, the title compound (1.69 g, 79%) was prepared from 2-amino-4-chlorobenzenethiol (1.6 g, 9.74 mmol), K2CO3 (3.36 g, 24.36 mmol) in DMF (20 ml).

後処理

  1. customThe solvent was removed

出典と根拠

ORDレコード
ord-e89e2658e1a74c058d94f6a230341b4f
出典データセット
uspto-grants-2016_05
特許番号
US09328067B2

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