Thionyl Chloride → 3-(Chloromethyl)-2-fluoropyridine

HRID 520879ノート

反応式

HRID 520879 の反応式
[F:1][C:2]1[C:7]([CH2:8]O)=[CH:6][CH:5]=[CH:4][N:3]=1.O=S(Cl)[Cl:12]>C(Cl)Cl>[Cl:12][CH2:8][C:7]1[C:2]([F:1])=[N:3][CH:4]=[CH:5][CH:6]=1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 147614612-Fluoro-3-(hydroxymethyl)pyridine

生成物 1

HCID 226413043-(Chloromethyl)-2-fluoropyridine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

(2-Fluoropyridin-3-yl)methanol (508 mg, 3.998 mmol) was first treated with SOCl2 (1.5 ml) in CH2Cl2 (5 ml) at rt for 3 hrs. The solvent was removed to get a crude 3-(chloromethyl)-2-fluoropyridine. Then following General Procedure A, the title compound (910 mg, 85%) was prepared from 2-amino-4-chlorobenzenethiol (957 mg, 5.995 mmol), K2CO3 (2.7 g, 19.98 mmol) in DMF (20 ml).

後処理

  1. customThe solvent was removed

出典と根拠

ORDレコード
ord-b888c59c4b9a41539bbe403e28eb93cf
出典データセット
uspto-grants-2016_05
特許番号
US09328067B2

反応ノート

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