3,4-dihydro-2H-pyran → 2H-Pyran, 2-(4-chlorobutoxy)tetrahydro-
反応式
[O:1]1[CH:6]=[CH:5][CH2:4][CH2:3][CH2:2]1.[Cl:7][CH2:8][CH2:9][CH2:10][CH2:11][OH:12]>Cl>[Cl:7][CH2:8][CH2:9][CH2:10][CH2:11][O:12][CH:6]1[CH2:5][CH2:4][CH2:3][CH2:2][O:1]1参加物
4
実験手順
Dihydropyran (15.5 g) was added dropwise to a mixture of 4-chlorobutanol (20 g) and hydrochloric acid (18 M, 1 drop) at RT. The mixture was stirred for 30 min and washed with H2O (100 ml), aqueous NaHCO3 (1 M, 50 ml) and BR (50 ml). The dried liquid was heated under reduced pressure to leave the title compound as a colourless liquid (31.9 g). T.l.c. [L] Rf 0.5.
後処理
- washwashed with H2O (100 ml), aqueous NaHCO3 (1 M, 50 ml) and BR (50 ml)
- temperatureThe dried liquid was heated under reduced pressure
出典と根拠
- ORDレコード
- ord-8d888550453845d89f366f2eeaefe39f
- 出典データセット
- uspto-grants-1993_09
- 特許番号
- US05243076
反応ノート
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