3,4-dihydro-2H-pyran → 2H-Pyran, 2-(4-chlorobutoxy)tetrahydro-

HRID 5214

反応式

HRID 5214 の反応式
[O:1]1[CH:6]=[CH:5][CH2:4][CH2:3][CH2:2]1.[Cl:7][CH2:8][CH2:9][CH2:10][CH2:11][OH:12]>Cl>[Cl:7][CH2:8][CH2:9][CH2:10][CH2:11][O:12][CH:6]1[CH2:5][CH2:4][CH2:3][CH2:2][O:1]1

参加物

4

反応物 2

HCID 80803,4-dihydro-2H-pyranHCID 135694-Chloro-1-butanol

生成物 1

HCID 1704882H-Pyran, 2-(4-chlorobutoxy)tetrahydro-収率 89.9%

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid触媒

実験手順

Dihydropyran (15.5 g) was added dropwise to a mixture of 4-chlorobutanol (20 g) and hydrochloric acid (18 M, 1 drop) at RT. The mixture was stirred for 30 min and washed with H2O (100 ml), aqueous NaHCO3 (1 M, 50 ml) and BR (50 ml). The dried liquid was heated under reduced pressure to leave the title compound as a colourless liquid (31.9 g). T.l.c. [L] Rf 0.5.

後処理

  1. washwashed with H2O (100 ml), aqueous NaHCO3 (1 M, 50 ml) and BR (50 ml)
  2. temperatureThe dried liquid was heated under reduced pressure

出典と根拠

ORDレコード
ord-8d888550453845d89f366f2eeaefe39f
出典データセット
uspto-grants-1993_09
特許番号
US05243076

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