Methyl iodide → Methyl 3-bromo-5-fluoro-4-methoxybenzoate
反応式
[CH3:1][O:2][C:3](=[O:13])[C:4]1[CH:9]=[C:8]([F:10])[C:7]([OH:11])=[C:6]([Br:12])[CH:5]=1.[C:14](=O)([O-])[O-].[K+].[K+].IC>CC(C)=O>[CH3:1][O:2][C:3](=[O:13])[C:4]1[CH:9]=[C:8]([F:10])[C:7]([O:11][CH3:14])=[C:6]([Br:12])[CH:5]=1参加物
5
実験手順
6 g (24.09 mmol) of the product obtained in step 1 were dissolved in 60 ml of acetone, 10.13 g (2.270 mmol) of potassium carbonate and 6.84 g (48.18 mmol) of iodomethane were added, and the mixture was stirred for 4 days. Then is was filtered and evaporated. The resulting product (5.8 g) was used in the next step without further purification.
後処理
- filtrationThen is was filtered
- customevaporated
- customThe resulting product (5.8 g) was used in the next step without further purification
出典と根拠
- ORDレコード
- ord-655597f546b3408f909ac54e3c6d0729
- 出典データセット
- uspto-grants-2016_05
- 特許番号
- US09328071B2
反応ノート
読み込み中…