3-Bromo-1,1,1-trifluoro-2-propanone → 6-Bromo-5-methyl-2-trifluoromethyl-2,3-dihydroimidazo [1,2-a]pyridin-2-ol hydrobromide
反応式
[Br:1][CH2:2][C:3](=[O:8])[C:4]([F:7])([F:6])[F:5].[NH2:9][C:10]1[CH:15]=[CH:14][C:13]([Br:16])=[C:12]([CH3:17])[N:11]=1>COCCOC>[BrH:1].[Br:16][C:13]1[CH:14]=[CH:15][C:10]2[N:11]([CH2:2][C:3]([C:4]([F:7])([F:6])[F:5])([OH:8])[N:9]=2)[C:12]=1[CH3:17]参加物
4
実験手順
A mixture of 1.91 g of 3-bromo-1,1,1-trifluoropropan-2-one and 10 ml of DME was added to a mixture of 1.87 g of 2-amino-5-bromo-6-methylpyridine and 10 ml of DME, and the mixture was stirred at room temperature for 3 hours. The precipitated solid was taken by filtration, washed with 10 ml of DME, and dried to obtain 3.39 g of 6-bromo-5-methyl-2-trifluoromethyl-2,3-dihydroimidazo [1,2-a]pyridin-2-ol hydrobromide.
後処理
- filtrationThe precipitated solid was taken by filtration
- washwashed with 10 ml of DME
- customdried
出典と根拠
- ORDレコード
- ord-8d56e6f7a3c540fbb7e2f97d51538589
- 出典データセット
- uspto-grants-2016_05
- 特許番号
- US09328121B1
反応ノート
読み込み中…