4-Chlorobenzyl alcohol → 1-(Bromomethyl)-4-chlorobenzene
反応式
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6]O)=[CH:4][CH:3]=1.P(Br)(Br)[Br:11]>C(Cl)Cl>[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][Br:11])=[CH:4][CH:3]=1参加物
4
実験手順
To a suspension of 4-chlorobenzyl alcohol (14.26 g, 100 mmol) in CH2Cl2 (40 mL) at ambient temperature was added added dropwise a solution of PBr3 in CH2Cl2 (1.0M, 32 mL, 32 mmol). The reaction mixture was stirred for 72 hours at ambient temperature and then was poured slowly onto ice. The layers were separated and the organic phase was dried over MgSO4, filtered, and concentrated in vacuo to give 4-chlorobenzyl bromide (19.76 g) as a colorless solid.
後処理
- additionwas added
- additionwas poured slowly onto ice
- customThe layers were separated
- dry with materialthe organic phase was dried over MgSO4
- filtrationfiltered
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-b84de76bff364798be1a6cb094b81efd
- 出典データセット
- uspto-grants-1997_04
- 特許番号
- US05616596
反応ノート
読み込み中…