4-Chlorobenzyl alcohol → 1-(Bromomethyl)-4-chlorobenzene

HRID 52181

反応式

HRID 52181 の反応式
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6]O)=[CH:4][CH:3]=1.P(Br)(Br)[Br:11]>C(Cl)Cl>[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][Br:11])=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 133974-Chlorobenzyl alcoholHCID 24614Phosphorus tribromide

生成物 1

HCID 693291-(Bromomethyl)-4-chlorobenzene

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

To a suspension of 4-chlorobenzyl alcohol (14.26 g, 100 mmol) in CH2Cl2 (40 mL) at ambient temperature was added added dropwise a solution of PBr3 in CH2Cl2 (1.0M, 32 mL, 32 mmol). The reaction mixture was stirred for 72 hours at ambient temperature and then was poured slowly onto ice. The layers were separated and the organic phase was dried over MgSO4, filtered, and concentrated in vacuo to give 4-chlorobenzyl bromide (19.76 g) as a colorless solid.

後処理

  1. additionwas added
  2. additionwas poured slowly onto ice
  3. customThe layers were separated
  4. dry with materialthe organic phase was dried over MgSO4
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-b84de76bff364798be1a6cb094b81efd
出典データセット
uspto-grants-1997_04
特許番号
US05616596

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