N-Iodosuccinimide → 2-Iodo-3-(4fluorophenylmethyl)thiophene

HRID 52188ノート

反応式

HRID 52188 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]2[CH:13]=[CH:12][S:11][CH:10]=2)=[CH:4][CH:3]=1.C(Cl)(Cl)Cl.CO.[I:20]N1C(=O)CCC1=O>C(Cl)Cl>[I:20][C:10]1[S:11][CH:12]=[CH:13][C:9]=1[CH2:8][C:5]1[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=1

参加物

5

反応物 3

HCID 120273N-IodosuccinimideHCID 199633023-(4-Fluorophenylmethyl)thiopheneHCID 21584188Chloroform methanol

生成物 1

HCID 199632792-Iodo-3-(4fluorophenylmethyl)thiophene収率 95.2%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 3-(4-fluorophenylmethyl)thiophene (1.16 g, 6.04 mmol) in 1:1 CHCl3 /methanol was added N-iodosuccinimide (1.70 g, 7.53 mmol). The reaction mixture was stirred for 3 hours, and then was diluted with CH2Cl2. The organic phase was extracted with saturated aqueous NaHCO3 and brine, dried over MgSO4, filtered, and concentrated in vacuo to give 1.83 g of 2-iodo-3-(4fluorophenylmethyl)thiophene which was used without further purification.

後処理

  1. extractionThe organic phase was extracted with saturated aqueous NaHCO3 and brine
  2. dry with materialdried over MgSO4
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-76414163d6a84d8b834fadd2b1086ec7
出典データセット
uspto-grants-1997_04
特許番号
US05616596

反応ノート

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