Diisopropylethylamine → HCID 178434563、化合物

To a solution of HATU (0.3 mmol, 113 mg) and 5-(2-chloro-5-(3-fluoropyridin-2-yl)benzamido)-1-phenyl-1H-pyrazole-3-carboxylic acid (Example 105, 0.23 mmol, 100 mg) in DMF (0.9 mL) was added DIPEA (1.10 mmol, 0.191 mL). The solution was stirred at room temperature for 15 minutes. 3-methyl-1H-pyrazol-4-amine (0.23 mmol, 100 mg) was added and the reaction stirred at room temperature for 18 hours. The reaction was diluted with EtOAc (20 mL), washed with NaHCO3 (20 mL), 10% aqueous citric acid solution (20 mL) and brine (20 mL). The organic layer was dried over sodium sulphate and concentrated in vacuo. The residue was purified using reverse phase column chromatography to afford the title compound as a yellow solid (35 mg, 29%).

1. stirringthe reaction stirred at room temperature for 18 hours
2. washwashed with NaHCO3 (20 mL), 10% aqueous citric acid solution (20 mL) and brine (20 mL)
3. dry with materialThe organic layer was dried over sodium sulphate
4. concentrationconcentrated in vacuo
5. customThe residue was purified

ORDレコード

ord-b079327898c0470c86cfb8b5e3eb952a

出典データセット

uspto-grants-2016_05

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US09328096B2