Hydrochloric Acid → 2-Chloro-4-fluoro-5-(3-fluoropyridin-2-yl)benzoic acid
反応式
[Cl:1][C:2]1[CH:11]=[C:10]([F:12])[C:9]([C:13]2[C:18]([F:19])=[CH:17][CH:16]=[CH:15][N:14]=2)=[CH:8][C:3]=1[C:4]([O:6]C)=[O:5].[Li+].[OH-].O.Cl>C(O)C>[Cl:1][C:2]1[CH:11]=[C:10]([F:12])[C:9]([C:13]2[C:18]([F:19])=[CH:17][CH:16]=[CH:15][N:14]=2)=[CH:8][C:3]=1[C:4]([OH:6])=[O:5]参加物
6
実験手順
To a mixture of methyl 2-chloro-4-fluoro-5-(3-fluoropyridin-2-yl)benzoate (Preparation 36, 240 mg, 0.85 mmol) in ethanol (5 mL) was added 2M LiOH in water (2.1 mL, 4.23 mmol). The reaction was stirred at room temperature for 1 hour before neutralising with 2M HCl (aq). The resulting precipitate was collected, washed with water and dried to afford the title compound as a white solid (160 mg, 70%).
後処理
- customThe resulting precipitate was collected
- washwashed with water
- customdried
出典と根拠
- ORDレコード
- ord-55f593576f824427b55ec44877b66e62
- 出典データセット
- uspto-grants-2016_05
- 特許番号
- US09328096B2
反応ノート
読み込み中…