Sodium Hydroxide → 4-Methyl-3-oxopentanoic acid

HRID 522241ノート

反応式

HRID 522241 の反応式
[OH-].[Na+].[C:3]([CH2:8][C:9]([O:11]C)=[O:10])(=[O:7])[CH:4]([CH3:6])[CH3:5]>O>[C:3]([CH2:8][C:9]([OH:11])=[O:10])(=[O:7])[CH:4]([CH3:6])[CH3:5]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 2759969Methyl 4-methyl-3-oxopentanoate

生成物 1

HCID 4400244-Methyl-3-oxopentanoic acid

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Sodium hydroxide (0.4 g) was dissolved in water (10 ml) and methyl isobutyrylacetate (manufactured by Fluka Corp., 1.44 g) was added thereto and stirred for 6 hours at room temperature. The reaction product was washed with ether and ether extraction was performed by adding a 10%-dilute sulfuric acid (4.9 g). An excess of anhydrous sodium sulfate was added to the ether extract, drying was performed thereon, and the anhydrous sodium sulfate was removed by filtering. In addition, the ether was removed using a rotary evaporator and an isobutyrylacetic acid was obtained (yield: 1 g).

後処理

  1. washThe reaction product was washed with ether and ether extraction
  2. additionby adding a 10%-dilute sulfuric acid (4.9 g)
  3. additionAn excess of anhydrous sodium sulfate was added to the ether
  4. extractionextract
  5. customdrying
  6. customthe anhydrous sodium sulfate was removed
  7. filtrationby filtering
  8. customIn addition, the ether was removed
  9. customa rotary evaporator

出典と根拠

ORDレコード
ord-ce490a7ad0dc4313add3ca603492e57b
出典データセット
uspto-grants-2016_05
特許番号
US09328254B2

反応ノート

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