4-Aminostyrene → 1-(4-Vinylphenyl)-3-[3,5-bis(trifluoromethyl)phenyl]thiourea

HRID 522337

反応式

HRID 522337 の反応式
[NH2:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[CH2:7])=[CH:4][CH:3]=1.[F:10][C:11]([F:26])([F:25])[C:12]1[CH:13]=[C:14]([N:22]=[C:23]=[S:24])[CH:15]=[C:16]([C:18]([F:21])([F:20])[F:19])[CH:17]=1>C1COCC1>[CH:6]([C:5]1[CH:8]=[CH:9][C:2]([NH:1][C:23]([NH:22][C:14]2[CH:15]=[C:16]([C:18]([F:19])([F:20])[F:21])[CH:17]=[C:12]([C:11]([F:10])([F:25])[F:26])[CH:13]=2)=[S:24])=[CH:3][CH:4]=1)=[CH2:7]

参加物

4

反応物 2

HCID 737004-AminostyreneHCID 27333953,5-Bis(trifluoromethyl)phenyl isothiocyanate

生成物 1

HCID 581124441-(4-Vinylphenyl)-3-[3,5-bis(trifluoromethyl)phenyl]thiourea収率 60%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a stirred solution of 4-aminostyrene (3.5 mmol) in dry THF (20 mL) under nitrogen was added 3,5-bis-(trifluoromethyl)phenyl isothiocyanate (3.5 mmol). The solution was refluxed overnight and then the solvent was evaporated under reduced pressure. The resulting solid residue was purified by column chromatography to yield the desired product in 60% yield.

後処理

  1. temperatureThe solution was refluxed overnight
  2. customthe solvent was evaporated under reduced pressure
  3. customThe resulting solid residue was purified by column chromatography

出典と根拠

ORDレコード
ord-3fe51d0a917048c28d43fc50b0e7264a
出典データセット
uspto-grants-2016_05
特許番号
US09329186B2

関連ノート

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