Ammonium Carbonate → (4-Nitrophenyl)methanesulfonamide

HRID 522678ノート

反応式

HRID 522678 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][S:11](Cl)(=[O:13])=[O:12])=[CH:6][CH:5]=1)([O-:3])=[O:2].C(=O)([O-])[O-].[NH4+:19].[NH4+]>C(#N)C.N>[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][S:11]([NH2:19])(=[O:13])=[O:12])=[CH:6][CH:5]=1)([O-:3])=[O:2]

参加物

5

反応物 2

HCID 517111Ammonium CarbonateHCID 2794642(4-Nitrophenyl)methanesulfonyl chloride

生成物 1

HCID 2755281(4-Nitrophenyl)methanesulfonamide収率 93%

試薬・触媒・溶媒 2

HCID 222Ammonia溶媒HCID 6342Acetonitrile溶媒

実験手順

To a solution of (4-nitrophenyl)methanesulfonyl chloride (4 g, 17 mmol) in acetonitrile (100 mL) was added a solution of ammonium carbonate (3 g, 31.3 mmol) in ammonia (50 mL). The reaction mixture was stirred for 1 h, and TLC indicated the starting material consumed completely. The organic solvent was removed under reduced pressure. Addition of water (10 mL) led to precipitate formation. The solid was collected, washed with water (2×5 mL), and dried to give (4-nitrophenyl)methanesulfonamide (3.4 g, 93%) as a white solid. MS (ES+) C7H8N2O4S requires: 216, found: 217 [M+H]+.

後処理

  1. customconsumed completely
  2. customThe organic solvent was removed under reduced pressure
  3. additionAddition of water (10 mL)
  4. customto precipitate formation
  5. customThe solid was collected
  6. washwashed with water (2×5 mL)
  7. customdried

出典と根拠

ORDレコード
ord-682bdb71b5c04a29b771059b4eb53331
出典データセット
uspto-grants-2016_05
特許番号
US09334263B2

反応ノート

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