Diisopropylethylamine → HCID 178461598、化合物

HRID 522802ノート

反応式

HRID 522802 の反応式
Cl[C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][NH:8]2)=[C:4]([N:11]2[CH2:16][CH2:15][O:14][CH2:13][C@H:12]2[CH3:17])[N:3]=1.C(N(C(C)C)CC)(C)C.Cl.[CH3:28][C@@H:29]1[CH2:34][O:33][CH2:32][CH2:31][NH:30]1>CC(O)CC.C(Cl)Cl>[CH3:28][C@@H:29]1[CH2:34][O:33][CH2:32][CH2:31][N:30]1[C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][NH:8]2)=[C:4]([N:11]2[CH2:16][CH2:15][O:14][CH2:13][C@H:12]2[CH3:17])[N:3]=1

参加物

6

反応物 3

HCID 81531DiisopropylethylamineHCID 57356922(3R)-3-Methylmorpholine hydrochlorideHCID 178461592HCID 178461592、化合物

生成物 1

HCID 178461598HCID 178461598、化合物

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 6568(+-)-2-Butanol溶媒

反応条件

温度
180 °C

実験手順

2-Chloro-6-((R)-3-methyl-morpholin-4-yl)-9H-purine (1.02 g, 4 mmol), diisopropylethylamine (1.40 mL, 8 mmol), and (R)-3-methylmorpholin hydrochloride (826 mg, 6 mmol) were stirred in 2-butanol (5 mL) in a closed microwave tube under argon at 50° C., until all ingredients were dissolved. The reaction was then stirred at 180° C. for 100 hours. The reaction mixture was then cooled to room temperature and diluted with 200 mL of CH2Cl2.

後処理

  1. dissolutionwere dissolved
  2. temperatureThe reaction mixture was then cooled to room temperature

出典と根拠

ORDレコード
ord-b947f4e924834d29af0e3d3298ae2880
出典データセット
uspto-grants-2016_05
特許番号
US09334271B2

反応ノート

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