HCID 67354024、化合物 → 5-Amino-2-hydroxy-N-methylbenzamide
反応式
C([O:8][C:9]1[CH:18]=[CH:17][C:16]([N+:19]([O-])=O)=[CH:15][C:10]=1[C:11]([NH:13][CH3:14])=[O:12])C1C=CC=CC=1>[Pd].CO>[NH2:19][C:16]1[CH:17]=[CH:18][C:9]([OH:8])=[C:10]([CH:15]=1)[C:11]([NH:13][CH3:14])=[O:12]参加物
4
実験手順
To a flask charged with 2-(benzyloxy)-N-methyl-5-nitrobenzamide (176 mg, 1.061 mmol) was added MeOH (4 mL). The resulting suspension was thoroughly purged with nitrogen prior to the addition of 10% Pd/C (12 mg, 0.046 mmol). The reaction mixture was purged with H2 gas, and then stirred under at atmosphere of hydrogen overnight. The reaction mixture was filtered through Celite® (diatomaceous earth) and the filtrate dried under reduced pressure. The resulting 5-amino-2-hydroxy-N-methylbenzamide (90 mg, 99% crude yield) was used in next step without further purification.
後処理
- customThe resulting suspension was thoroughly purged with nitrogen
- customThe reaction mixture was purged with H2 gas
- filtrationThe reaction mixture was filtered through Celite® (diatomaceous earth)
- customthe filtrate dried under reduced pressure
- customThe resulting 5-amino-2-hydroxy-N-methylbenzamide (90 mg, 99% crude yield) was used in next step without further purification
出典と根拠
- ORDレコード
- ord-e7562d999bc24e8182f7d9f22f68fc9c
- 出典データセット
- uspto-grants-2016_05
- 特許番号
- US09334269B2
反応ノート
読み込み中…