Trifluoroacetic acid → 3-(2,4-Dichlorophenoxy)azetidine
反応式
[Cl:1][C:2]1[CH:19]=[C:18]([Cl:20])[CH:17]=[CH:16][C:3]=1[O:4][CH:5]1[CH2:8][N:7](C(OC(C)(C)C)=O)[CH2:6]1.FC(F)(F)C(O)=O>C(Cl)Cl>[Cl:1][C:2]1[CH:19]=[C:18]([Cl:20])[CH:17]=[CH:16][C:3]=1[O:4][CH:5]1[CH2:8][NH:7][CH2:6]1参加物
4
実験手順
To a solution of tert-butyl 3-(2,4-dichlorophenoxy)azetidine-1-carboxylate (1.2 g, 3.78 mmol) in CH2Cl2 (10 mL) was added trifluoroacetic acid (TFA) (7 mL) and the reaction mixture was stirred at RT for 2 h. The mixture was concentrated under reduced pressure and filtered, washing with chloroform followed by diethyl ether to obtain 3-(2,4-dichlorophenoxy) azetidine (0.800 g, 100%) as a TFA salt.
後処理
- concentrationThe mixture was concentrated under reduced pressure
- filtrationfiltered
- washwashing with chloroform
出典と根拠
- ORDレコード
- ord-2792ccd22e434f51b05e19f96909c590
- 出典データセット
- uspto-grants-2016_05
- 特許番号
- US09334269B2
反応ノート
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