4-bromo-1-methyl-1H-pyrazole-5-carbaldehyde → (4-bromo-1-methyl-1H-pyrazol-5-yl)methanol

HRID 523107

反応式

HRID 523107 の反応式
[Br:1][C:2]1[CH:3]=[N:4][N:5]([CH3:9])[C:6]=1[CH:7]=[O:8].[BH4-].[Na+]>CO>[Br:1][C:2]1[CH:3]=[N:4][N:5]([CH3:9])[C:6]=1[CH2:7][OH:8]

参加物

4

反応物 2

HCID 27946344-bromo-1-methyl-1H-pyrazole-5-carbaldehydeHCID 4311764Sodium borohydride

生成物 1

HCID 57415773(4-bromo-1-methyl-1H-pyrazol-5-yl)methanol収率 90%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 4-bromo-1-methyl-1H-pyrazole-5-carbaldehyde (677 mg, 3.58 mmol) in MeOH (8 mL) at 0° C., NaBH4 (136 mg, 0.86 mmol) was added. The solution was stirred at room temperature for 2 hours. The reaction was concentrated in vacuo and diluted with water. The solution was extracted with EtOAc, the organic layer collected, dried over sodium sulphate and concentrated in vacuo to afford the title compound as a white solid (614 mg, 90%).

後処理

  1. concentrationThe reaction was concentrated in vacuo
  2. additiondiluted with water
  3. extractionThe solution was extracted with EtOAc
  4. customthe organic layer collected
  5. dry with materialdried over sodium sulphate
  6. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-292f601f3fab4682ac53935aab33a93b
出典データセット
uspto-grants-2016_05
特許番号
US09334286B2

関連ノート

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