Potassium Phosphate, Tribasic → HCID 66576811、化合物

HRID 523593ノート

反応式

HRID 523593 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([N:8]2[CH2:12][CH2:11][NH:10][C:9]2=[O:13])[CH:5]=[CH:4][N:3]=1.Br[C:15]1[CH:16]=[N:17][CH:18]=[CH:19][C:20]=1[C:21]1([OH:26])[CH2:25][CH2:24][CH2:23][CH2:22]1.CN[C@@H]1CCCC[C@H]1NC.P([O-])([O-])([O-])=O.[K+].[K+].[K+]>[Cu](I)I.O1CCOCC1>[Cl:1][C:2]1[CH:7]=[C:6]([N:8]2[CH2:12][CH2:11][N:10]([C:15]3[CH:16]=[N:17][CH:18]=[CH:19][C:20]=3[C:21]3([OH:26])[CH2:25][CH2:24][CH2:23][CH2:22]3)[C:9]2=[O:13])[CH:5]=[CH:4][N:3]=1

参加物

7

反応物 4

HCID 62657Potassium Phosphate, TribasicHCID 2733821trans-N,N'-dimethyl-1,2-cyclohexanediamineHCID 20636580HCID 20636580、化合物HCID 70982889HCID 70982889、化合物

生成物 1

HCID 66576811HCID 66576811、化合物収率 11.1%

試薬・触媒・溶媒 2

HCID 83717Copper iodide触媒HCID 312751,4-Dioxane溶媒

実験手順

Using analogous reagents and reaction conditions as described in Example 1 above, 1-(2-chloro-pyridin-4-yl)imidazolidin-2-one (I-33b: 100 mg, 0.5 mmol) was reacted with 1-(3-bromo-pyridin-4-yl)-cyclopentanol (I-34a: 135 mg, 0.558 mmol), copper iodide (9.6 mg, 0.05 mmol), trans-N,N′-dimethylcyclohexane-1,2-diamine (21.62 mg, 0.15 mmol), potassium phosphate (322.87 mg, 1.52 mmol) and 1,4-dioxane (5 mL) to yield the crude product. Purification by preparative HPLC afforded 20 mg of the product (11% yield).

後処理

  1. customreagents and reaction conditions
  2. customto yield the crude product
  3. customPurification by preparative HPLC

出典と根拠

ORDレコード
ord-a8c51218c22445dc8fad5d766597084b
出典データセット
uspto-grants-2016_05
特許番号
US09339501B2

反応ノート

読み込み中…