Toluene → Methyl 3-(4-methylphenyl)benzoate
反応式
I[C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][CH:11]=1)[C:5]([O:7][CH3:8])=[O:6].[C:12]1([CH3:18])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>IC1C=CC(C)=CC=1.[Cu]>[CH3:18][C:12]1[CH:17]=[CH:16][C:15]([C:2]2[CH:11]=[CH:10][CH:9]=[C:4]([C:5]([O:7][CH3:8])=[O:6])[CH:3]=2)=[CH:14][CH:13]=1参加物
5
実験手順
To a mixture of methyl 3-iodobenzoate (26.1 g) in 4-iodotoluene (21.9 g) was added copper powder (31.8 g) gradually at 180°-190° C. The mixture was then stirred for 6 hours at 200°-210° C. The reaction mixture was cooled to room temperature, to which was added toluene. Insoluble materials were filtered off, and the filtrate was concentrated to dryness. The residue was purified by column chromatography on silica gel to afford the title compound as a colorless oil (6.61 g, 29%).
後処理
- filtrationInsoluble materials were filtered off
- concentrationthe filtrate was concentrated to dryness
- customThe residue was purified by column chromatography on silica gel
出典と根拠
- ORDレコード
- ord-2fe8b08f64c844be852d3e2cfd2c0a0e
- 出典データセット
- uspto-grants-1993_09
- 特許番号
- US05243054
反応ノート
読み込み中…