Toluene → Methyl 3-(4-methylphenyl)benzoate

HRID 5237

反応式

HRID 5237 の反応式
I[C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][CH:11]=1)[C:5]([O:7][CH3:8])=[O:6].[C:12]1([CH3:18])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>IC1C=CC(C)=CC=1.[Cu]>[CH3:18][C:12]1[CH:17]=[CH:16][C:15]([C:2]2[CH:11]=[CH:10][CH:9]=[C:4]([C:5]([O:7][CH3:8])=[O:6])[CH:3]=2)=[CH:14][CH:13]=1

参加物

5

反応物 2

HCID 1140TolueneHCID 69258Methyl 3-iodobenzoate

生成物 1

HCID 1394187Methyl 3-(4-methylphenyl)benzoate収率 29%

試薬・触媒・溶媒 2

HCID 23978Copper触媒HCID 122074-Iodotoluene溶媒

実験手順

To a mixture of methyl 3-iodobenzoate (26.1 g) in 4-iodotoluene (21.9 g) was added copper powder (31.8 g) gradually at 180°-190° C. The mixture was then stirred for 6 hours at 200°-210° C. The reaction mixture was cooled to room temperature, to which was added toluene. Insoluble materials were filtered off, and the filtrate was concentrated to dryness. The residue was purified by column chromatography on silica gel to afford the title compound as a colorless oil (6.61 g, 29%).

後処理

  1. filtrationInsoluble materials were filtered off
  2. concentrationthe filtrate was concentrated to dryness
  3. customThe residue was purified by column chromatography on silica gel

出典と根拠

ORDレコード
ord-2fe8b08f64c844be852d3e2cfd2c0a0e
出典データセット
uspto-grants-1993_09
特許番号
US05243054

関連ノート

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