Benzyl Bromide → 4-(Benzyloxy)-2-bromopyridine

HRID 523918ノート

反応式

HRID 523918 の反応式
[H-].[Na+].[Br:3][C:4]1[CH:9]=[C:8]([OH:10])[CH:7]=[CH:6][N:5]=1.[CH2:11](Br)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.CCOC(C)=O>CN(C=O)C>[CH2:11]([O:10][C:8]1[CH:7]=[CH:6][N:5]=[C:4]([Br:3])[CH:9]=1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

参加物

6

反応物 4

HCID 7498Benzyl BromideHCID 8857Ethyl AcetateHCID 24758Sodium hydrideHCID 178516474HCID 178516474、化合物

生成物 1

HCID 153891994-(Benzyloxy)-2-bromopyridine収率 51.2%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

NaH (761 mg, 19.83 mmol) was added portion wise to 2-bromo-4-hydroxypyridine (3 g, 17.24 mmol) in DMF (50 mL) at 0° C. under Ar(g). Then the reaction mixture was stirred at rt for 10 min after which it was again cooled down at 0° C. and benzyl bromide (2.15 mL, 18.10 mmol) was added. The reaction was stirred at it for 4 h, after which it was poured onto brine (200 mL) and EtOAc (200 mL) was added. The phases were separated and the organic phase was dried over MgSO4, filtered and subsequently evaporated under reduced pressure. The resulting residue was purified by silica gel column chromatography eluting with hexane/EtOAc (90:10 to 80:20) to furnish I as a white solid (2.331 g, 51%).

後処理

  1. temperaturewas again cooled down at 0° C.
  2. stirringThe reaction was stirred at it for 4 h
  3. additionwas added
  4. customThe phases were separated
  5. dry with materialthe organic phase was dried over MgSO4
  6. filtrationfiltered
  7. customsubsequently evaporated under reduced pressure
  8. customThe resulting residue was purified by silica gel column chromatography
  9. washeluting with hexane/EtOAc (90:10 to 80:20)

出典と根拠

ORDレコード
ord-2bffd9e2d85942cbb70d04b1477d6fef
出典データセット
uspto-grants-2016_05
特許番号
US09340503B2

反応ノート

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