Benzoyl chloride → 2-Chloroethylbenzoate

HRID 52396

反応式

HRID 52396 の反応式
[C:1](Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N(CC)CC)C.[Cl:17][CH:18](O)[CH3:19].C1C[O:24]CC1>>[C:1]([O:8][CH2:19][CH2:18][Cl:17])(=[O:24])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 4

HCID 7412Benzoyl chlorideHCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 126390351-Chloroethan-1-ol

生成物 1

HCID 959522-Chloroethylbenzoate収率 99%

実験手順

20.0 g (142 mM) of benzoyl chloride and then additionally 14.4 g (142 mM) of triethylamine were added dropwise with vigorous stirring at room temperature to a solution of 11.5 g (142 mM) of chloroethanol in 200 ml of THF (exothermic reaction). After stirring for 1 h, the mixture was concentrated on a rotary evaporator, and the residue was partitioned between methylene chloride and water and acidified with 10% strength hydrochloric acid. The aqueous phase was reextracted twice with methylene chloride and the organic phase was then concentrated after drying with sodium sulfate. 26.0 g (99%) of 2-chloroethyl benzoate were isolated.

後処理

  1. concentrationthe mixture was concentrated on a rotary evaporator
  2. customthe residue was partitioned between methylene chloride and water
  3. concentrationthe organic phase was then concentrated
  4. dry with materialafter drying with sodium sulfate

出典と根拠

ORDレコード
ord-c5ebfe6e19984f1aabaa307bac8ba7d0
出典データセット
uspto-grants-1997_04
特許番号
US05616705

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