Potassium Carbonate → 3-Bromo-2-(cyclopropylmethoxy)benzaldehyde

HRID 523995ノート

反応式

HRID 523995 の反応式
[Br:1][C:2]1[C:9]([OH:10])=[CH:8][CH:7]=[CH:6][C:3]=1C=O.Br[CH2:12][CH:13]1[CH2:15][CH2:14]1.[C:16]([O-:19])([O-])=O.[K+].[K+]>CN(C=O)C.O>[Br:1][C:2]1[CH:3]=[CH:6][CH:7]=[C:8]([C:16]=1[O:19][CH2:12][CH:13]1[CH2:15][CH2:14]1)[CH:9]=[O:10]

参加物

6

反応物 3

HCID 11430Potassium CarbonateHCID 81503BromomethylcyclopropaneHCID 37146742-Bromo-3-hydroxybenzaldehyde

生成物 1

HCID 597250443-Bromo-2-(cyclopropylmethoxy)benzaldehyde

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

実験手順

300 mg (1.49 mmol) 2-Bromo-3-hydroxy-benzaldehyde, 302 mg (2.24 mmol) (bromomethyl)cyclopropane and 412 mg (2.99 mmol) K2CO3 in 3 mL DMF are stirred at 80° C. over night. Afterwards the reaction mixture is diluted with water and extracted with EtOAc. The organic layer is separated and dried over Na2SO4, filtered and the solvent is removed in vacuo.

後処理

  1. extractionextracted with EtOAc
  2. customThe organic layer is separated
  3. dry with materialdried over Na2SO4
  4. filtrationfiltered
  5. customthe solvent is removed in vacuo

出典と根拠

ORDレコード
ord-1ee4c086c6534256b2b3745d812ea9f3
出典データセット
uspto-grants-2016_05
特許番号
US09340510B2

反応ノート

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