2-Amino-5-bromobenzenemethanol → 2-Amino-5-bromobenzaldehyde

HRID 524033ノート

反応式

HRID 524033 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][C:3]=1[CH2:9][OH:10]>C(Cl)Cl.O=[Mn]=O>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][C:3]=1[CH:9]=[O:10]

参加物

4

反応物 1

HCID 110308742-Amino-5-bromobenzenemethanol

生成物 1

HCID 235104752-Amino-5-bromobenzaldehyde収率 81%

試薬・触媒・溶媒 2

HCID 14801Manganese dioxide触媒HCID 6344Dichloromethane溶媒

実験手順

A mixture of (2-amino-5-bromophenyl)methanol (10 g, 49.5 mmol) and MnO2 (25.8 g, 296.6 mmol) in CH2Cl2 (400 mL) was stirred at RT overnight. LCMS showed the reaction was completed. The solid was filtered off, and the filtrate was concentrated to give the title compound as a light yellow solid (8 g, 81%), which was directly used in next step without further purification. MS (ES+) C7H6BrNO requires: 199. found: 200, 202 [M+H]+.

後処理

  1. filtrationThe solid was filtered off
  2. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-cce5a4d41af44cbe996d2618a96c8642
出典データセット
uspto-grants-2016_05
特許番号
US09340514B2

反応ノート

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