N-bromobutanimide → 2-Amino-5-bromo-3-fluorobenzoic acid

HRID 524076

反応式

HRID 524076 の反応式
[NH2:1][C:2]1[C:10]([F:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[Br:12]N1C(=O)CCC1=O>ClCCl>[NH2:1][C:2]1[C:10]([F:11])=[CH:9][C:8]([Br:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

参加物

4

反応物 2

HCID 67184N-bromobutanimideHCID 5864082-Amino-3-fluorobenzoic acid

生成物 1

HCID 404245972-Amino-5-bromo-3-fluorobenzoic acid収率 78%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of 2-amino-3-fluorobenzoic acid (10.85 g, 70 mmol) in dichloromethane (175 mL) was added N-bromosuccinimide (12.46 g, 70 mmol), and the mixture was stirred at RT for 2 h. LCMS showed the reaction was completed. The precipitate was filtered and washed with dichloromethane (100 mL*3) to give the title compound (12.7 g, 78%) as a grey solid, which was directly used in the next step without further purification. MS (ES+) C7H5BrFNO2 requires: 233, 235. found: 232, 234 [M−H]−.

後処理

  1. filtrationThe precipitate was filtered
  2. washwashed with dichloromethane (100 mL*3)

出典と根拠

ORDレコード
ord-7dae895f0fd64c8e98396060340921c5
出典データセット
uspto-grants-2016_05
特許番号
US09340514B2

関連ノート

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