Oxalyl chloride → 5-(Benzyloxy)-2-methylbenzoyl chloride

HRID 524320ノート

反応式

HRID 524320 の反応式
[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([CH3:18])=[C:13]([CH:17]=1)[C:14](O)=[O:15])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(Cl)(=O)C([Cl:22])=O>C(Cl)Cl>[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([CH3:18])=[C:13]([CH:17]=1)[C:14]([Cl:22])=[O:15])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 65578Oxalyl chlorideHCID 597600475-(Benzyloxy)-2-methylbenzoic acid2 回

生成物 1

HCID 866574365-(Benzyloxy)-2-methylbenzoyl chloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a mixture of 3.3 g 5-(benzyloxy)-2-methylbenzoic acid (compound F1) in 80 ml DCM are added 1.4 ml of oxaloylchloride, and the reaction is stirred at RT over night under a blanket of nitrogen. The solvent is removed under reduced pressure yielding the title compound, which was used without further purification.

後処理

  1. customThe solvent is removed under reduced pressure

出典と根拠

ORDレコード
ord-2cfccea2aea04d5cab4c9ef385a394f4
出典データセット
uspto-grants-2016_05
特許番号
US09340522B2

反応ノート

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